Elastin polymorphism haplotype and intracranial aneurysms are not associated in Central Europe.
نویسندگان
چکیده
BACKGROUND AND PURPOSE The occurrence of intracranial aneurysms and of aneurysmal subarachnoid hemorrhage are influenced by genetic factors. Recent genomic studies in Japan have defined 3 chromosomal loci and 1 haplotype of elastin polymorphisms as important risk factors, both for affected sib pairs and sporadic patients. METHODS We have genotyped 2 single nucleotide polymorphisms in the elastin gene and evaluated their allelic association with intracranial aneurysm in a Central European sample of 30 familial and 175 sporadic patients and 235 population controls. RESULTS We found no allelic association between this elastin polymorphism haplotype and intracranial aneurysm. CONCLUSIONS Our data probably reflect increased genetic heterogeneity of intracranial aneurysm in Europe compared with Japan.
منابع مشابه
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عنوان ژورنال:
- Stroke
دوره 34 5 شماره
صفحات -
تاریخ انتشار 2003